Milan is at the heart of the European rail network and the key interchange for the national network.
Two rail companies operate in Milan: Trenitalia for national and international routes (Central Station)
and Ferrovie Nord for local transport (Cadorna Station).
Frequency of direct trains
| COUNTRY | DESTINATIONS | WEEKLY JOURNEYS |
| AUSTRIA | Linz | 56 |
| Vienna |
| Salzburg |
| Innsbruck |
| Klagenfurt |
| CROATIA | Zagreb | 42 |
| FRANCE | Nice | 126 |
| Paris |
| Gujon |
| Lyon |
| Chamberry |
| HUNGARY | Budapest | 42 |
| GERMANY | Dortmund | 112 |
| Frankfurt |
| Mannheim |
| Munich |
| SLOVENIA | Lubjana | 42 |
| SPAIN | Barcelona | 14 |
| SWITZERLAND | Zurich | 336 |
| Basel |
| Geneva |
| Schaffausen |
| Lucerne |
| Bern |